David Sinclair，男，美国哈佛大学医学院遗传学系教授，Paul F. Glenn衰老生物机制研究实验室主任

1995年毕业于澳大利亚的悉尼市的新南威尔士大学，并获得分子遗传学博士学位。

1999年被招募到哈佛大学医学院，此后16年一直在教授衰老生物学与衰老转化医学。

Aging, NY (2008-2020年) 联合主编，联合创立人

2018年参与的演讲

2018, Nov Regeneron, NY

2018, Nov AFAR Conference on Aging, NY

2018, Nov Owners Forum, Oman

2018, Nov Australian Consulate, NY

2018, Oct Discovery Museum, Acton, MA

2018, Oct Innovation Meeting, Boston, MA, NASA iTech

2018, Oct Symposium on Aging and NIV, BWH, Boston

2018, Sept CNIO/Madrid Meeting on Aging

2018, July HHMI Workshop, HMS

2018, June EdenRoc Meeting, Santa Cruz

2018, May Convergence conference, Cape Cod

2018, May CNIO Spain, Conference on Aging, Madrid

2018, May The University of Washington, Stem Cell Meeting

2018, Apr Arc Fusion Conference, Boston. Radical Wellness

2018, Apr Young Professional Organization, Boston

2018, Apr Young Jewish Professionals, NY

2018, Mar Longwood Seminars, Keynote Speaker, Harvard Medical School

2018, Feb Genetics Department Retreat, Harvard Medical School

2018, Feb Seminar to veterinary staff, Harvard Medical School

2017年参与的演讲

2017, Nov Pepper Center, Symposium on NAD precursors. Harvard Medical School

2017, Oct a16z Andreessen Horowitz Conference, Las Vegas

2017, Oct IUBMB Symposium on Aging, Athens Greece, Plenary Lecturer

2017, Sept CLSA Investor Conference, Hong Kong

2017, Aug FASEB meeting on acetylation and sirtuins, Big Sky Montana

2017, Aug AFAR Board Meeting, Advances in Aging Research

2017, July New Orleans FASEB meeting on NAD

2017, June Harvard/Paul F. Glenn Symposium

2017, June Charoen Pokphand, Thailand, invited speaker

2017, June Charles Perkins Center, Sydney, Australia

2017, June Carlyle Investor Conference, JFK Center, Boston

2017, June AMPlify Conference, Sydney Australia

2017, May Harvard Med. School, Brigham and Women’s Hospital Grand Rounds

2017, May University of Washington, Grad Student invited speaker

2017, May University of Rochester, Invited Speaker

2017, May University of Virginia, Aging and Healthspan Conference

2017, Apr Australian Biology of Aging Meeting, Sydney

2017, Apr NASA panel speaker, Space Conference, Colorado Springs, CO.

2017, Mar Aging and Senescence meeting, Harvard Medical School

2017, Mar Fusion Conference on Aging, 2017, Cancun, Mexico

2017, Feb The Kastan Lecture, USC, named lecture

2017, Jan Conference on Aging and Aging-based Therapeutics, Scripps Florida

Genomics/Sensors/Biotracking:

Dovetail Genomics, an EdeRoc Company, Scotts Valley CA, parent company EdenRoc Sciences (2015-present) E

Revere Biosensors, an EdenRoc Company, Menlo Park, CA, parent company EdenRoc Sciences (2015- present) F,I,E,A,B (EdenRoc)

UpRNA, an EdenRoc Sciences company (2018-2020) E

Claret Bioscience, an EdenRoc Sciences company (2018-present) E

Pharmaceuticals/Biotech:

Sirtris Pharma, Cambridge MA Medicines, rare, common diseases, sirtuin activation (2004-2010) F,I,A,B,IP

GlaxoSmithKline, Sirtuins, A (2010-2016), IP (2010-2020)

Cohbar Menlo Park CA, fatty liver disease, peptides (2010-2020) F,E,A

RD project of NMN series of products of Intero Nutrition, Natual Life Nutrition Inc. (2019-2020), E,A

OvaScience, MA, fertility solutions (2012-2015) IP

Galilei Biosciences, SIRT6 activators (2014-2020) F,I,E,A,B

Jupiter Orphan Therapeutics, rare diseases (2016-present) E,A

MetroBiotech, an EdenRoc company, aka Bauhaus; NAD boosters (2015-present) F,I,E,A,B (EdenRoc),IP

Life Biosciences, Boston, MA Longevity technologies, see listed affiliates (2017-present) F,I,E,A,B,IP

Senolytic Therapeutics, a Life Biosciences Company, Senolytics (2017-present) F,I,E,A,B

Spotlight Biosciences, a Life Biosciences company, Cambridge, MA (2018-present) F,I,E,A,B,IP

Selphagy, a Life Biosciences company, Barcelona, Spain, New York, NY (2018-present) I,E

Iduna, a Life Biosciences Company, Boston, MA (2018-present) F,I,E,A,IP

Immetas, a Life Biosciences Company, Boston, MA (2018-present) F,I,E,A,B

Jumpstart Fertility, a Life Biosciences Company, Sydney, Australia, Boston, MA F,I,E,A,B,IP

Continuum Biosciences, a Life Biosciences Company, Blacksburg, Virgina, Boston, MA F,I,E,A,B

Biosecurity / Medical Genomics:

Liberty Biosecurity, an EdenRoc company (2015-present) F,I,E,A,B (EdenRoc), IP

Consumer / Biotracking

InsideTracker (Segterra), Cambridge, MA I,A,IP (2011-present) B(2011-2017)

Caudalie, Paris, France (2013-present) IP,L

Elysium Health, New York, NY (2018) IP

Shaklee, Pleasanton, CA (2008) A

Animal Health/Husbandry

Animal Biosciences, a Life Biosciences company (2017-present) I,E,B

Vium, formerly Mousera, Menlo Park, CA (2013-present) I,E,A

Agriculture:

Bayer Crop Science (2006-present) IP

the CSL Prize CSL奖

The Australian Commonwealth Prize澳大利亚英联邦奖

Thompson Prize 汤普森奖

Helen Hay Whitney Postdoctoral Award 惠特尼博士后奖学金

Charles Hood Fellowship 奖学金

Leukemia Society Fellowship 美国白血病与淋巴瘤学会奖学金

Ludwig Scholarship 奖学金

Harvard-Armenise Fellowship 奖学金

American Association for Aging Research Fellowship 美国老化研究协会奖学金

Nathan Shock Award from the National Institutes of Health 美国国立卫生研究院的Nathan Shock 奖

Ellison Medical Foundation Junior and Senior Scholar Awards 埃里森医学基金会奖学金

Merck Prize 默克奖

Genzyme Outstanding Achievement in Biomedical Science Award， Genzyme 生物医学成就奖

Bio-Innovator Award 生物创新奖

David Murdock-Dole Lectureship 戴维默多克- 都乐教学奖

Fisher Honorary Lectureship 加州大学洛杉矶分校的费沙荣誉教研奖

Les Lazarus Lectureship 教学奖

Australian Medical Research Medal 澳大利亚医学研究奖章

The Frontiers in Aging and Regeneration Award 衰老与再生前沿奖

Top 100 Australian Innovators 澳大利亚创新百强

TIME magazine’s list of the “100 most influential people in the world” 时代杂志的“全球100位最具影响力人物”

2019年参与发表的论文

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.

Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1.

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Epigenetic changes during aging and their reprogramming potential.

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles.

2018年参与发表的论文

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.

Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects.

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles.

Sirtuin activators and inhibitors: Promises, achievements, and challenges.

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

Assays for NAD+-Dependent Reactions and NAD+ Metabolites.